Jun Shimizu Selected Research

Relapsing Polychondritis

9/2021	Serum MMP3 Correlated With IL1β Messenger RNA Expressions of Peripheral Blood Mononuclear Cells in Patients With Relapsing Polychondritis With Respiratory Involvement.
1/2018	Propionate-producing bacteria in the intestine may associate with skewed responses of IL10-producing regulatory T cells in patients with relapsing polychondritis.
1/2014	Serum level of soluble triggering receptor expressed on myeloid cells-1 as a biomarker of disease activity in relapsing polychondritis.

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Jun Shimizu Research Topics

Disease

12	Aortic Valve Stenosis (Aortic Stenosis) 07/2022 - 04/2012
11	Myositis (Idiopathic Inflammatory Myopathies) 01/2022 - 04/2010
10	Neoplasms (Cancer) 01/2022 - 10/2005
8	Inflammation (Inflammations) 02/2022 - 04/2006
7	Muscular Diseases (Myopathy) 01/2022 - 07/2012
4	Autoimmune Diseases (Autoimmune Disease) 01/2020 - 02/2002
3	Polymyositis 01/2022 - 05/2007
3	Relapsing Polychondritis 09/2021 - 01/2014
3	Dementia (Dementias) 08/2021 - 09/2015
3	Disease Progression 01/2021 - 01/2013
3	Muscle Weakness 01/2020 - 06/2012
3	Stroke (Strokes) 10/2017 - 01/2012
3	Sepsis (Septicemia) 10/2017 - 10/2006
3	Behcet Syndrome (Behcet's Syndrome) 07/2016 - 01/2012
3	Glomerulonephritis 05/2009 - 10/2002
2	Thymoma (Thymic Carcinoma) 05/2022 - 01/2019
2	Inclusion Body Myositis 01/2022 - 01/2020
2	COVID-19 01/2022 - 12/2021
2	Infections 12/2021 - 01/2012
2	Cognitive Dysfunction 08/2021 - 09/2015
2	Myasthenia Gravis 01/2021 - 01/2019
2	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2020 - 02/2004
2	Fibrosis (Cirrhosis) 03/2019 - 02/2006
2	Acute Kidney Injury (Acute Renal Failure) 11/2018 - 10/2017
2	Encephalitis (Encephalitis, Rasmussen) 10/2018 - 01/2006
2	Muscular Dystrophies (Muscular Dystrophy) 03/2018 - 06/2016
2	Aortic Valve Insufficiency (Aortic Regurgitation) 10/2017 - 12/2016
2	Bone Resorption 08/2017 - 11/2015
2	Polyneuropathies (Polyneuropathy) 12/2016 - 02/2011
2	Parkinsonian Disorders (Parkinsonism) 02/2016 - 12/2006
2	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 01/2015 - 04/2003
2	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 01/2013 - 06/2012
2	Rheumatic Diseases (Rheumatism) 04/2012 - 03/2010
2	Aneurysm (Aneurysms) 04/2012 - 10/2002
2	Wounds and Injuries (Trauma) 08/2007 - 10/2006
2	Virus Diseases (Viral Diseases) 05/2004 - 03/2003
1	Tetralogy of Fallot (Fallot Tetralogy) 10/2022
1	Plasmacytoma 07/2022
1	POEMS Syndrome (Syndrome, POEMS) 07/2022
1	Genomic Instability 07/2022
1	Multiple Myeloma 07/2022
1	Mitochondrial Diseases (Mitochondrial Disease) 07/2022
1	1 Rippling muscle disease 05/2022
1	Bronchogenic Cyst 05/2022
1	Hyperglycemia 02/2022
1	Hypertrophy 02/2022
1	Cytokine Release Syndrome 01/2022

Drug/Important Bio-Agent (IBA)

12	AntibodiesIBA 05/2022 - 04/2007
7	AutoantibodiesIBA 01/2022 - 04/2006
5	CytokinesIBA 07/2022 - 03/2010
5	Proteins (Proteins, Gene)FDA Link 07/2022 - 10/2005
5	Creatine Kinase (Creatine Phosphokinase)IBA 01/2021 - 06/2012
3	Oxidoreductases (Dehydrogenase)IBA 01/2022 - 12/2016
3	Messenger RNA (mRNA)IBA 09/2021 - 03/2010
3	CollagenIBA 03/2010 - 03/2003
3	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 04/2006 - 02/2004
3	GlucocorticoidsIBA 04/2006 - 02/2004
2	Cholinergic ReceptorsIBA 05/2022 - 01/2019
2	Insulin (Novolin)FDA Link 02/2022 - 01/2020
2	Glucose (Dextrose)FDA LinkGeneric 02/2022 - 12/2008
2	Aspartate Aminotransferases (Aspartate Transaminase)IBA 01/2022 - 12/2008
2	Signal Recognition ParticleIBA 01/2022 - 06/2016
2	Alanine Transaminase (SGPT)IBA 01/2022 - 12/2008
2	Interleukin-6 (Interleukin 6)IBA 01/2022 - 12/2021
2	Cholinergic Agents (Cholinergics)IBA 08/2021 - 09/2015
2	Immune Checkpoint InhibitorsIBA 01/2020 - 01/2019
2	GadoliniumIBA 01/2020 - 05/2008
2	Peptides (Polypeptides)IBA 01/2017 - 01/2006
2	EnzymesIBA 12/2016 - 06/2012
2	ImmunosorbentsIBA 12/2016 - 06/2012
2	DNA (Deoxyribonucleic Acid)IBA 01/2015 - 05/2004
2	Ataxin-1IBA 01/2015 - 04/2003
2	Intravenous Immunoglobulins (IVIG)FDA Link 11/2013 - 01/2012
2	ChondroitinIBA 10/2013 - 02/2011
2	Interleukin-12 (IL 12)IBA 01/2013 - 06/2009
2	LipopolysaccharidesIBA 06/2009 - 10/2006
2	Peroxidase (Myeloperoxidase)IBA 05/2009 - 10/2002
2	Antineutrophil Cytoplasmic Antibodies (ANCA)IBA 05/2009 - 10/2002
2	HydrogelsIBA 08/2007 - 10/2006
2	ChitosanIBA 08/2007 - 10/2006
2	Caveolin 1IBA 10/2006 - 02/2006
2	Monoclonal AntibodiesIBA 10/2005 - 02/2002
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 07/2022
1	Pyruvic Acid (Pyruvate)IBA 07/2022
1	Lactic Acid (Lactate)FDA LinkGeneric 07/2022
1	LipidsIBA 02/2022
1	Immune Checkpoint ProteinsIBA 01/2022
1	Cadherins (E-Cadherin)IBA 01/2022
1	RNA (Ribonucleic Acid)IBA 01/2022
1	Nicotine FDA Link 01/2022
1	CholesterolIBA 01/2022
1	Cell Adhesion MoleculesIBA 01/2022

Therapy/Procedure

12	Transcatheter Aortic Valve Replacement 07/2022 - 07/2013
11	Therapeutics 01/2020 - 05/2008
2	Immunotherapy 01/2022 - 11/2011
2	Transplantation 01/2017 - 01/2012
2	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 09/2013 - 03/2013
2	Anesthesia 04/2012 - 05/2003
1	Surgical Instruments (Clip) 10/2022
1	Thymectomy 05/2022